In vivo islet protection by a nuclear import inhibitor in a mouse model of type 1 diabetes.
Insulin-dependent Type 1 diabetes (T1D) is a devastating autoimmune disease that destroys beta cells within the pancreatic islets and afflicts over 10 million people worldwide.These patients face life-long risks for blindness, cardiovascular and renal diseases, and complications of insulin treatment.New therapies that protect islets from autoimmune